Our research at the molecular scale focuses on biophysical approaches to understand the interaction between pharmaceutical compounds and molecular targets.
Applications of our work include cardiac safety pharmacology assays and approaches to detect and investigate neurotoxicity, as well as biosensor- and force-spectroscopy-based analyses of molecular interactions (see e.g. Möller et al., 2023; Loser et al., 2021a; Loser et al., 2021b).
Key methods in our laboratory include:
Atomic Force Microscopy (AFM)
(Automated) Patch Clamp Electrophysiology
Customized Biosensors
Acoustic Spectroscopy and Sound Analysis
Environmental particle analysis (PM2.5 / PM10)
Radiation measurements using Geiger detection
In silico and in vitro safety pharmacology
These techniques enable high-resolution investigation of molecular interactions, cellular responses, and toxicological effects.